PARIS: A third of people hospitalised with Covid-19 have “abnormalities” in multiple organs months after getting infected, a UK study said on Saturday, potentially shedding light on the elusive condition of long Covid.
Millions worldwide are estimated to suffer from long Covid, in which a range of symptoms such as shortness of breath, fatigue and brain fog last long after patients first contract the virus.
Yet much about the condition, including exactly how Covid causes such a wide range of symptoms, remains unknown.
The authors of the new study, published in “The Lancet Respiratory Medicine”, said it marks a “step forward” in helping long-Covid sufferers.
The study is the first to look at magnetic resonance imaging (MRI) scans of multiple organs – the brain, heart, liver, kidneys and lungs – after being hospitalised with Covid.
It compared the organ scans of 259 adults hospitalised with Covid across the United Kingdom in 2020-2021 with a control group of 52 people who never contracted the virus.
Nearly a third of the Covid patients had abnormalities in more than one organ an average of five months after leaving hospital, the study found.
Those hospitalised with Covid were 14 times more likely to have lung abnormalities, and were three times more likely to have abnormalities in their brain, it said.
However, hearts and livers appeared to be more resilient, the researchers added.
Abnormalities in the brain included a higher rate of white brain lesions, which have been linked to mild cognitive decline; while scarring and signs of inflammation were among the changes seen in lungs.
‘Concrete evidence’
Individuals with multiple organ abnormalities were four times more likely to report severe mental and physical impairment, making them “unable to perform their daily activities”, lead author Betty Raman from Oxford University said.
The study was conducted during an earlier phase of the pandemic, before mass immunity from vaccination and prior infection blunted the overall severity of Covid.
It also did not cover the less-severe Omicron variants that remain dominant around the world. And the Covid group was slightly older and generally less healthy than the control group, although the researchers sought to adjust their findings to account for these differences.
Nevertheless, people are still being hospitalised due to the virus across the world, the researchers emphasised.
Study co-author Christopher Brightling of Leicester University said the study provides “concrete evidence there are changes in a number of organs” after people are hospitalised with Covid.
Rather than being a cause for alarm, he said the finding is a “step forwards in terms of actually being able to help people with long Covid”.
Matthew Baldwin, a pulmonary disease specialist at Columbia University not involved in the study, said “these results suggest that long Covid is not explained by severe deficits concentrated in any one organ”.
“Rather, the interaction of two or more abnormalities in organs might have an additive or multiplicative effect in creating physiological deficits that result in long Covid symptoms,” he wrote in a “Lancet” comment article.