Rafa, Pizzi, Grimaldo and Chiquinho got on the scoresheet to secure the cup for Benfica.
Joao Felix’s acquisition is to replace Antoine Griezmann who is reportedly set to leave Atletico Madrid.
Benfica coach Bruno Lage warned against getting carried away with the performance of Joao Felix, who only made his first-team debut this season.
Luka Jovic wants to prove to Benfica his worth in Thursday's Europa League quarter-final clash in Lisbon.
It is the biggest win in 54 years in the Portuguese championship after Benfica clobbered Seixal 11-3 in 1965.
Hummels has been laid out by gastroenteritis, which has also hit his wife Cathy and 10-month-old baby son Ludwig.
In Ajax's 1-1 draw against Benfica, André Onana's error allowed Benfica to score, but he also made a crucial save to prevent the Lisbon club from taking all three points.
In a match between two sides who lost their opening Group E games, Benfica raced to a two-goal lead in 15 minutes through Haris Seferovic and Alex Grimaldo.
Renato Sanches inspired Bayern Munich to a 2-0 victory over his former club Benfica.
Benfica claimed that the allegations were groundless and vowed to prove their innocence.
PSV Eindhoven came from behind to beat BATE Borisov 3-2, while Benfica and Red Star Belgrade drew 1-1 and 0-0 against PAOK and Red Bull Salzburg respectively.
Standard Liège came back from a two-goal deficit to register a 2-2 draw against Ajax Amsterdam, while a Franco Cervi goal gave Benfica a 1-0 win over Fenerbahçe.
Alisson is a key signing for Jurgen Klopp who was desperate for a new goalkeeper to replace Loris Karius.
Talisca set up Guangzhou's first goal and added three of his own in a 4-0 thrashing of bottom-dwellers Guizhou Zhicheng.