Witnesses reported ash spewing out of the 2,334 metre summit, sending trails spanning high overhead.
The eruption of Mount Agung on Indonesia's resort island Bali prompts cancellations of flights both to and from the island.
Its last major eruption in 2010 killed more than 300 people and forced some 280,000 others to evacuate.
On Sunday morning, the volcano sent ash skywards as it erupted for about three minutes.
A spokesman for Guatemala's disaster management agency CONRED said 2,995 residents in the municipality of Escuintla and two other districts were moved to shelters as a precaution.
Indonesia's state disaster agency warned people to stay at least four kilometres (two and a half miles) away but said there was no need to evacuate for the time being.
A change in lava flow direction would destroy more residential areas after at least 712 homes were torched and thousands of residents forced to evacuate since Kilauea began erupting on May 3.
Apart from the deaths, the eruption of Volcán de Fuego caused an estimated US$219 million worth of damage.
It previously said 197 people had gone missing since the eruptions of dust, ash and super-heated gas known as pyroclastic flows that began on June 3 at the Fuego volcano, its strongest activity in four decades.
Ngurah Rai airport began operating around 2:30 pm local time (0730 GMT), about 12 hours after it closed in response to Mt. Agung belching smoke and ash.
The president's action is due to the aftermath of a series of recent volcanic eruptions, said Marta Larra, a spokesperson for Guatemala's Foreign Ministry.
Shinmoedake, in a mainly rural area about 985 km (616 miles) from Tokyo had quietened down since the earlier eruption, although admission to the 1,421-metre- (4,662-ft-) high peak remained restricted.
US President Donald Trump approved federal emergency housing aid and other relief for victims of the six-week-old Kilauea Volcano eruption on Hawaii's Big Island, where homes have been destroyed.
Fears of a new blowup of the 3,763-meter (12,346-foot) volcano have stalked rescue workers since Sunday's eruption buried entire villages on its southern flank.
The Hawaiian County Civil Defense Agency said rock falls and gas explosions from one of the craters on Kilauea had caused the ash plume.
Lava flowing from giant rips in the earth on the flank of Hawaii's erupting Kilauea volcano threatened highways on Monday, raising the possibility officials may order thousands more people to evacuate before escape routes are cut off.
The Indonesian government ordered residents living within a five-kilometre (three-mile) radius of Mount Merapi on Java to leave.
The explosions from Kilauea, which began five days ago, paused on Tuesday long enough for many of the roughly 1,700 people ordered to flee their homes.
Japan's iconic Mount Fuji could paralyse Tokyo with ash if it erupted, choking roads and halting water supplies, according to a government disaster planning study, a news report said Tuesday.
After the initial eruption, Ioyama is likely to soon erupt again.
Due to the impending eruption of Manaro Voui, residents of Ambae have had to evacuate the island.
Mount Shinmoedake had been erupting on a smaller scale since March 1, when entrance to the 1,421 metre-high peak was restricted.
Japan's Meteorological Agency has deemed Mount Zaō to be more likely to erupt.
The eruption of Mount Mayon has, ironically, drawn many tourists to the area.
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