Rafael Nadal has been battling with a knee-injury for quite some time, this time he retires from the Indian Wells semi-finals due to unbearable pain.
He says his failure to defend his Australian Open title changes nothing and his aim is the same as always - to beat Rafael Nadal and Novak Djokovic.
With his record seventh crown at Melbourne Park, Djokovic moved ahead of Pete Sampras as third on the men's all-time list of most Grand Slam titles.
Despite the rout, Nadal says he is content with being able to even reach the final given the injury problems that prevented him from playing any matches after the US Open.
Djokovic came out all guns blazing and broke Nadal in the Spaniard's first service game to race ahead 4-1 in the opening set.
Sharapova is set up with a tricky clash against in-form Barty who will have huge home support on Rod Laver Arena in a prime-time afternoon showdown.
MELBOURNE: Former champion Rafa Nadal showed no signs of discomfort from his thigh strain as he sailed through to the second round of the...
The season-opening tournament boasts a stellar field with Kei Nishikori and Grigor Dimitrov also in contention.
When questioned whether that was because Nadal was injured, the new world number one said "yes".
The injury forced Nadal to withdraw from his US Open semi-final against Juan Martin del Potro.
Djokovic, who received a first-round bye, could pass Roger Federer at number two in world rankings if he reaches Sunday's final.
He will be replaced by world number 52 Albert Ramos-Vinolas for the September 14-16 clash against France.
Djokovic, the 2011, 2014 and 2015 champion, will face Kevin Anderson, the first South African in the final in 97 years, for the title after a 5-hour 15-minute marathon.
Juan Martin del Potro lay sprawled face down on the slippery and dusty Centre Court turf as Nadal punched away a final backhand volley to seal a 7-5 6-7(7) 4-6 6-4 6-4 win that took him into the semi-finals for the first time since 2011.
He completed a 7-6(1) 7-6(5) 5-7 7-6(5) win over Frenchman Gilles Simon after fading light interrupted their last-16 clash the previous evening with the fifth seed up two sets to one.
Eight-time champion Federer needed just 16 minutes to win the opening set on his way to a 6-0, 7-5, 6-4 defeat of France's Adrian Mannarino to reach his 16th All England Club quarter-final.
The pair are again the two best players in the world and have split the last six Grand Slam titles between them - taking their combined haul to an incredible 37 major titles.
Zverev, playing for the third day in succession, was shocked by Latvian qualifier Ernests Gulbis, ranked 138, in a gruelling five sets, 7-6 (7/2), 4-6, 5-7, 6-3, 6-0.
Muguruza's defeat leaves just top seed Simona Halep, number seven Karolina Pliskova and 10th seed Madison Keys as the remaining top-ranked contenders after two rounds.
The US Open will have a shot clock for this year's tournament with Wimbledon poised to follow suit.
Sharapova, the 2004 champion, was joined at the exit by 2011 and 2014 winner Petra Kvitova who was stunned by Belarusian world number 50 Aliaksandra Sasnovich.
Nadal extended his incredible record on the red dirt of Roland Garros earlier this month as he crushed Dominic Thiem to win his 11th French Open title.
The Spanish grand slam great, Alonso's compatriot, was making his first visit to the Sarthe circuit as official starter after winning at Roland Garros for a record 11th time last weekend.
The 32-year-old is drained after playing 27 matches on clay over the last two months and has hinted after the final that the toll on his body might force him to miss part of the grass-court campaign.
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