The Madrid derby comes to the shores of the Black Sea in the last 16 with Uruguayan captain Diego Godín, of Atlético Madrid, and his club team-mate José María Giménez coming up against Real and Portugal’s five-time Ballon d’Or winner.
It will be a fascinating battle at the Fisht Stadium with Ronaldo, at 33, enjoying his best World Cup but Uruguay the only side to come through the group stage in Russia without conceding a goal.
Godín is an expert at keeping clean sheets, as the leader of an Atlético defense that is the most formidable in the European club game, and of a Uruguay side that has not conceded a goal in 2018 in six games.
Ronaldo, though, has already scored four times at this World Cup, including a hat-trick on his last visit here when Portugal drew 3-3 with Spain. That means he has 85 international goals, more than any other male European player in history.
In the last two years, he has scored two hat-tricks for Real against Godín’s Atlético, having also emerged victorious in two Madrid derby Champions League finals.
But the rugged and brave Godín, who needed reconstructive dental surgery after having three teeth punched out in an aerial challenge with Valencia’s goalkeeper earlier this year, has succeeded in muzzling Ronaldo on plenty of other occasions at club level going back almost a decade.
“Godín is a star. He defends, commands, scores goals, wins titles, and does not miss a game,” said Diego Maradona recently.
On Saturday, Giménez, who scored Uruguay’s late winner against Egypt, is set to rejoin Godín in central defense after missing the 3-0 victory over Russia due to injury.
Ronaldo, meanwhile, will look to get back among the goals having had a penalty saved in Portugal’s 1-1 draw with Iran. That, and the VAR-awarded late spot-kick for the Iranians, condemned the defending European champions to this tie rather than a meeting with the hosts in Moscow.
Portugal surely would have preferred that, for while Uruguay continue to produce tough centre-backs, they are by no means completely reliant on them.
This is a side boasting Italy-based midfielders in Rodrigo Bentancur, Lucas Torreira, and Matías Vecino, and up front they boast two of the greatest goalscorers of their generation in Luis Suárez and Edinson Cavani.
Suárez might lack the same sharpness of old, but he has still scored twice in Russia. One more and he will equal 1950 World Cup-winner Óscar Míguez’s Uruguayan record of eight goals at the tournament.
“They are a typical South American side,” said Portugal coach Fernando Santos.
“It’s not just in this World Cup that they have not been conceding goals. It has been like that for the whole of 2018. Óscar Tabárez is the longest-serving international manager. That means he has a very strong relationship with his players.”
These two countries with a combined population of 13.5 million have long been overachievers on the international scene – the last decade under Tabárez has seen two-time former winners Uruguay reach one World Cup semifinal and win one Copa America, while Portugal triumphed at Euro 2016.
The Uruguayans hold their opponents in equally high regard, conscious that Ronaldo is supported by younger talents like Bernardo Silva and Gonçalo Guedes.
“We will mark him with the same respect we mark everyone, despite him being a superstar,” said Sebastian Coates of Ronaldo. “You don’t prepare a match just looking at one player.”