Defender Matteo Darmian put Inter in front in the 26th minute with a low strike from the edge of the box before Lautaro Martinez doubled the advantage in first-half stoppage time, firing a powerful shot inside the left post.

Federico Dimarco added a third for Inter in the 54th minute, netting on the follow-up after Atalanta keeper Marco Carnesecchi saved a penalty from Martinez, and Davide Frattesi nodded home an Alexis Sanchez freekick to seal the win.

Inter are on 69 points from 26 games, comfortably ahead of second-placed Juventus and rivals AC Milan in third. Atalanta are fifth with 46 points, two adrift of fourth-placed Bologna.